Clinical research on the use of progestogens in transgender women is very limited. Endocrine treatment of transsexual people: The extent of these changes and the time interval for maximum change varies across patients and may take up to 18 to 24 months to occur. Endocrine treatment of transsexual persons: Spontaneous and morning erections decrease significantly in frequency, although some patients who have had an orchiectomy still experience morning erections.
It has been suggested that progestins be added during the last week of each cycle of estrogen therapy in order to develop more rounded breasts rather than the conical breasts many of these patients develop, but we have been unable to detect any difference in breast contour with or without progestins.
Transgender hormone therapy (male-to-female)
The risk of permanent infertility increases with long-term use of hormones, especially when hormone therapy is initiated before puberty. Stigma, mental health, and resilience in an online sample of the US transgender population. Most providers start testosterone therapy with half the anticipated dose needed to reach maximum virilization in a patient. Future research should observe these trends among a larger sample of participants. Oxford University Press; Management of Gender Dysphoria: Transgender health in Massachusetts:
Many transgender individuals seek cross-sex hormone therapy for treatment of gender dysphoria. Special considerations Routine laboratory monitoring of patients on cross-sex hormone therapy can be challenging because results are often reported using gender-specific reference intervals, which are not all appropriate for transgender patients. University of California, San Francisco: All patients had a normal male phenotype 46, XY chromosome karyotypeand none of them had previously undergone an orchiectomy. Endocrinology of the Testis and Male Reproduction.