A Narrative Review". This page was last edited on 29 Marchat In addition, diabetes is a significant risk factor for cardiovascular disease and may have an important role in raising the risk of cardiovascular morbidity in trans women on estrogen, as this comorbidity has been found to be prevalent among the transgender population Health care and medicine. PR Newswire.
Spironolactone is an aldosterone antagonist and a relatively weak antiandrogen that blocks the AR and inhibits androgen biosynthesis.
Women with complete androgen insensitivity syndrome 46,XY karyotype never develop male sex characteristics and have normal and complete female morphologyincluding breast development,  yet have not been reported to develop breast cancer. In these cases, and most adolescent cases, it is important to have a multi-disciplinary approach to treatment and management, and parental support is imperative. Karger Medical and Scientific Publishers.
The breasts were then developed more intensively with daily injections of oestradiol dipropionate and progesterone for 6 weeks.